Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases.
Antioxid Redox Signal
; 11(10): 2429-41, 2009 Oct.
Article
en En
| MEDLINE
| ID: mdl-19358632
ABSTRACT
The NADPH oxidase (Nox) enzyme family generates reactive oxygen species (ROS) that contribute to cell signaling, innate immune responses, proliferation, and transcription. The signaling mechanisms that regulate this important enzyme family are only beginning to be understood. Evidence is emerging which suggests that phosphorylation of Nox and/or their regulatory components may be important means of modulating their activity. We describe here the evidence for Nox regulation through the action of kinases, and speculate on how such regulatory mechanisms might contribute to the development of pathological disease states.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Especies Reactivas de Oxígeno
/
NADPH Oxidasas
/
Isoenzimas
Límite:
Humans
Idioma:
En
Revista:
Antioxid Redox Signal
Asunto de la revista:
METABOLISMO
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos