Id3 restricts the developmental potential of gamma delta lineage during thymopoiesis.
J Immunol
; 182(9): 5306-16, 2009 May 01.
Article
en En
| MEDLINE
| ID: mdl-19380777
ABSTRACT
Most T cell progenitors develop into the alphabeta T cell lineage with the exception of a small fraction contributing to the gammadelta lineage throughout postnatal life. T cell progenitors usually commit to the alphabeta lineage upon the expression of a fully rearranged and functional TCRbeta gene, and most cells that fail to produce a functional TCRbeta-chain will die instead of adopting the alternative gammadelta T cell fate. What prevents these cells from continuing TCRgamma rearrangement and adopting the gammadelta T cell fate is not known. In this study, we show that functional loss of Id3 results in a significant increase of gammadelta T cell production from progenitor cells undergoing TCRbeta rearrangement. The enhanced gammadelta T cell development correlated with increased TCRgamma gene rearrangement involving primarily Vgamma1.1 in Id3 deficient mice. We further show that Id3 deficiency promotes gammadelta T cell production in a manner independent of TCRbeta-chain expression. Our data indicates that Id3 suppresses Vgamma1.1 rearrangement and gammadelta lineage potential among T cell progenitors that have completed TCRbeta gene rearrangement without producing a functional TCRbeta protein.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Timo
/
Diferenciación Celular
/
Receptores de Antígenos de Linfocitos T gamma-delta
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Reordenamiento Génico de la Cadena delta de los Receptores de Antígenos de los Linfocitos T
/
Reordenamiento Génico de la Cadena gamma de los Receptores de Antígenos de los Linfocitos T
/
Linaje de la Célula
/
Proteínas Inhibidoras de la Diferenciación
Límite:
Animals
Idioma:
En
Revista:
J Immunol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos