Who's in charge? Nuclear receptor coactivator and corepressor function in brain and behavior.
Front Neuroendocrinol
; 30(3): 328-42, 2009 Aug.
Article
en En
| MEDLINE
| ID: mdl-19401208
ABSTRACT
Steroid hormones act in brain and throughout the body to regulate a variety of functions, including development, reproduction, stress and behavior. Many of these effects of steroid hormones are mediated by their respective receptors, which are members of the steroid/nuclear receptor superfamily of transcriptional activators. A variety of studies in cell lines reveal that nuclear receptor coregulators are critical in modulating steroid receptor-dependent transcription. Thus, in addition to the availability of the hormone and the expression of its receptor, nuclear receptor coregulators are essential for efficient steroid-dependent transactivation of genes. This review will highlight the importance of nuclear receptor coregulators in modulating steroid-dependent gene expression in brain and the regulation of behavior.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Represoras
/
Conducta
/
Encéfalo
/
Transactivadores
/
Receptores Citoplasmáticos y Nucleares
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Front Neuroendocrinol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos