Prevalence of qnr determinants among extended-spectrum beta-lactamase-positive Enterobacteriaceae clinical isolates in southern Stockholm, Sweden.
Int J Antimicrob Agents
; 34(3): 268-70, 2009 Sep.
Article
en En
| MEDLINE
| ID: mdl-19409763
ABSTRACT
Three hundred and nineteen extended-spectrum beta-lactamase-positive Enterobacteriaceae clinical isolates were screened for qnr genes. Twelve isolates were positive for qnr, including one qnrA1, two qnrB1, three qnrB2, one qnrB4, one qnrB6 and four qnrS1. No qnr-positive strains were identified among the isolates recovered before 2006. The first qnr-positive Escherichia coli was detected from a patient in 2006. qnr genes remained rare in E. coli (6/288; 2.1%), but appeared to be more prevalent in Klebsiella pneumoniae (4/25; 16%) and Enterobacter cloacae (2/3; 66.7%). All qnr-positive isolates were resistant to nalidixic acid while presenting varied susceptibilities to fluoroquinolones. Isolates harbouring qnrB4 or qnrB6 were highly resistant to all the fluoroquinolones tested. Their high-level resistance is associated with multiple chromosomal substitutions in gyrA and parC. Alterations at codons Ser-83 and Asp-87 in GyrA and at codons Ser-80 and Glu-84 in ParC were observed in these isolates.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Proteínas Bacterianas
/
Beta-Lactamasas
/
Enterobacteriaceae
/
Infecciones por Enterobacteriaceae
Tipo de estudio:
Prevalence_studies
/
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Int J Antimicrob Agents
Año:
2009
Tipo del documento:
Article
País de afiliación:
Suecia