Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naive rats.
Science
; 324(5935): 1732-4, 2009 Jun 26.
Article
en En
| MEDLINE
| ID: mdl-19478142
ABSTRACT
The neural mechanisms underlying the transition from a drug-nondependent to a drug-dependent state remain elusive. Chronic exposure to drugs has been shown to increase brain-derived neurotrophic factor (BDNF) levels in ventral tegmental area (VTA) neurons. BDNF infusions into the VTA potentiate several behavioral effects of drugs, including psychomotor sensitization and cue-induced drug seeking. We found that a single infusion of BDNF into the VTA promotes a shift from a dopamine-independent to a dopamine-dependent opiate reward system, identical to that seen when an opiate-naïve rat becomes dependent and withdrawn. This shift involves a switch in the gamma-aminobutyric acid type A (GABAA) receptors of VTA GABAergic neurons, from inhibitory to excitatory signaling.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Recompensa
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Área Tegmental Ventral
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Factor Neurotrófico Derivado del Encéfalo
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Trastornos Relacionados con Opioides
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2009
Tipo del documento:
Article
País de afiliación:
Canadá