Trisulfonated porphyrazines: new photosensitizers for the treatment of retinal and subretinal edema.
J Med Chem
; 52(14): 4107-10, 2009 Jul 23.
Article
en En
| MEDLINE
| ID: mdl-19514748
ABSTRACT
A new series of water-soluble, mononaphthotrisulfobenzoporphyrazines, bearing an alkynyl side chain of varying lengths on the naphtho ring, were prepared and tested for their efficacy to inhibit plasma extravasation when used as photosensitizers during photodynamic therapy (PDT) of the retina in the rat. The hexynyl substituted photosensitizer was the most potent, and was able to produce complete inhibition, at low doses of photosensitizer and light.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Porfirinas
/
Papiledema
/
Fármacos Fotosensibilizantes
Límite:
Animals
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Canadá