Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase.
Bioorg Med Chem Lett
; 19(15): 4350-3, 2009 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-19515564
ABSTRACT
The synthesis and optimisation of HCV NS5B polymerase inhibitors with improved potency versus the existing compound 1 is described. Substitution in the benzothiadiazine portion of the molecule, furnishing improvement in potency in the high protein Replicon assay, is highlighted, culminating in the discovery of 12h, a highly potent oxyacetamide derivative.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Benzotiadiazinas
/
Química Farmacéutica
/
Proteínas no Estructurales Virales
/
Hepacivirus
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos