[Anti-lipidperoxidation and cerebral protective effects of clausenamide].
Yao Xue Xue Bao
; 26(3): 166-70, 1991.
Article
en Zh
| MEDLINE
| ID: mdl-1957655
ABSTRACT
Clausenamide is a compound isolated from Clausena lansium (lour) with the structure similar to piracetam. Pharmacological experiments showed that clausenamide po 100-200 mg/kg prolonged both the duration of gasping after decapitation and the survival time after sc NaNO2 225 mg/kg, clausenamide at the concentration of 10(-5) mol/L inhibited the contraction of basilar artery caused by 5-HT, PGF2 alpha and arachidonic acid, indicating that clausenamide is a cerebral protective agent. In addition, multiple doses clausenamide were shown to inhibit the liver lipid peroxidation caused by 50% alcohol and increase the GSH-peroxidase activity significantly in rat liver and brain cytosol.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vasoconstricción
/
Vasodilatadores
/
Arteria Basilar
/
Peroxidación de Lípido
/
Lignanos
/
Lactamas
Límite:
Animals
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Año:
1991
Tipo del documento:
Article