Design, synthesis, and structure-activity relationship of tropane muscarinic acetylcholine receptor antagonists.
J Med Chem
; 52(16): 5241-52, 2009 Aug 27.
Article
en En
| MEDLINE
| ID: mdl-19630384
Novel tropane derivatives were characterized as muscarinic acetylcholine receptor antagonists (mAChRs). Through optimization of the structure-activity relationship around the tropane scaffold, the quaternary ammonium salt 34 was identified as a very potent M(3) mAChR antagonist. The compound was functionally active and displayed greater than 24 h duration of action in a mouse model of bronchoconstriction.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tropanos
/
Compuestos de Bifenilo
/
Antagonistas Muscarínicos
/
Compuestos Bicíclicos Heterocíclicos con Puentes
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos
