Paraquat detoxication with multiple emulsions.
Int J Pharm
; 380(1-2): 142-6, 2009 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-19635538
ABSTRACT
In this study, we show that detoxifying W/O/W multiple emulsions, prepared with an appropriate extractant/trapping couple, represent a promising technology for quick and safe poisoning treatments, with application to the highly toxic herbicide Paraquat, responsible of poisonings from low-dose exposure leading to several deaths every year. In vitro tests led to the choice of an appropriate extractant/trapping couple system with significant detoxication performance. In vivo tests showed (i) that rats receiving high doses of Paraquat, then a detoxifying emulsion, presented an increase from 50% to 100% of the MST (median survival time) and (ii) that no mortality was observed during 30 days with rats dosed with emulsions initially loaded with Paraquat at a concentration much higher than the lethal dose, proving the stability and the inocuity of the detoxifying multiple emulsion in the gastrointestinal tract.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Paraquat
/
Desintoxicación por Sorción
/
Emulsiones
Límite:
Animals
Idioma:
En
Revista:
Int J Pharm
Año:
2009
Tipo del documento:
Article
País de afiliación:
Francia