Hepatic Sinusoidal Obstruction Syndrome in a child after chemotherapy for medulloblastoma.
J Neurooncol
; 97(1): 137-41, 2010 Mar.
Article
en En
| MEDLINE
| ID: mdl-19701718
ABSTRACT
Hepatic Sinusoidal Obstruction Syndrome (HSOS), the new name given to veno-occlusive disease (VOD) of the liver, is a well-known complication of high-dose chemotherapy employed with hematopoietic stem cell transplantation, but it has rarely been observed in children who receive conventional chemotherapy. HSOS following standard chemotherapy has been reported in patients receiving vincristine, actinomycin D, and cyclophosphamide for the treatment of Wilms tumor and more rarely rhabdomyosarcoma. We report a 14-year-old boy with high risk medulloblastoma treated with craniospinal radiation followed by chemotherapy, who experienced severe HSOS after only one course of chemotherapy including carboplatin, vincristine, and cyclophosphamide. To our knowledge, this is the second report of HSOS after standard dose chemotherapy for brain tumor in childhood.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vincristina
/
Enfermedad Veno-Oclusiva Hepática
/
Terapia Combinada
/
Antineoplásicos Fitogénicos
Límite:
Adolescent
/
Humans
/
Male
Idioma:
En
Revista:
J Neurooncol
Año:
2010
Tipo del documento:
Article
País de afiliación:
Emiratos Árabes Unidos