A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease.
Neurosci Lett
; 468(1): 1-2, 2010 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-19837132
ABSTRACT
Several observations suggest that neurotoxicity in Alzheimer's disease (AD) can be partly attributed to beta-amyloid (Abeta) and senile plaques. Recent work has suggested that the FISH (five SH3 domains) adapter protein and ADAM12 (a disintegrin and metalloprotease) may mediate the neurotoxic effect of Abeta. Both genes are located on chromosome 10, within a region linked to AD (for SH3PXD2A) or nearby (for ADAM12). A recent study reported a statistically significant interaction between 2 variants of these genes (rs3740473 for SH3PXD2A and rs11244787 for ADAM12) with respect to the risk of developing AD. With a view to replicating this observation, we genotyped the two SNPs in four European case-control cohorts of Caucasian origin (1913 cases and 1468 controls) but were unable to confirm the initial results.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Adaptadoras del Transporte Vesicular
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Proteínas ADAM
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Enfermedad de Alzheimer
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Proteínas de la Membrana
Tipo de estudio:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Neurosci Lett
Año:
2010
Tipo del documento:
Article
País de afiliación:
Francia