Cerebrospinal fluid of brain trauma patients inhibits in vitro neuronal network function via NMDA receptors.
Ann Neurol
; 66(4): 546-55, 2009 Oct.
Article
en En
| MEDLINE
| ID: mdl-19847897
ABSTRACT
Neurological diseases frequently induce pathological changes of cerebrospinal fluid (CSF) that might secondarily influence brain activity, as the CSF-brain barrier is partially permeable. However, functional effects of CSF on neuronal network activity have not been specified to date. Here, we report that CSF specimens from patients with reduced Glasgow Coma Scale values caused by severe traumatic brain injury suppress synchronous activity of in vitro-generated neuronal networks in comparison with controls. We present evidence that underlying mechanisms include increased N-methyl-D-aspartate receptor activity mediated by a CSF fraction containing elevated amino acid concentrations. These proof-of-principle data suggest that determining effects of CSF specimens on neuronal network activity might be of diagnostic value.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Lesiones Encefálicas
/
Líquido Cefalorraquídeo
/
Receptores de N-Metil-D-Aspartato
/
Red Nerviosa
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Ann Neurol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Alemania