A case-control study on risk factors of osteoporosisin patients with Crohn's disease.
Arch Iran Med
; 12(6): 570-5, 2009 Nov.
Article
en En
| MEDLINE
| ID: mdl-19877750
ABSTRACT
BACKGROUND:
Osteoporosis has been frequently reported in patients with inflammatory bowel diseases, especially Crohn's disease.METHODS:
All consecutive Crohn's disease patients who attended the GI Clinics at Shariati Hospital, Tehran, Iran, from 2004 to 2007 were evaluated. A BMD-DEXA assessment was performed for all patients. Among those patients diagnosed with osteoporosis (T scoreRESULTS:
In this study, a multivariable modeling technique revealed a higher osteoporosis risk in those who had a lower body mass index, previous fractures and longer disease duration. A cumulative corticosteroid dose of 10 - 35 g provided the highest osteoporosis risk. Age, sex, bowel resection, site of disease, smoking and consumption of calcium and vitamin D did not show any relationship with osteoporosis.CONCLUSION:
The highest osteoporosis risk was seen in patients with a cumulative 10 - 35 g corticosteroid dose and could be due to both steroid inefficiency in reducing Crohn's disease inflammation as well as the cumulative drug dose and it's adverse effect on patients.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteoporosis
/
Enfermedad de Crohn
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Arch Iran Med
Año:
2009
Tipo del documento:
Article
País de afiliación:
Irán