[Effect of long-term sevoflurane anesthesia on markers of myocardial damage].
Zhonghua Yi Xue Za Zhi
; 89(27): 1916-8, 2009 Jul 21.
Article
en Zh
| MEDLINE
| ID: mdl-19953916
ABSTRACT
OBJECTIVE:
To investigate the effect of long-term sevoflurane anesthesia on markers of myocardial damage or toxicity.METHODS:
Forty adult patients scheduled for upper abdominal surgery with general anesthesia for 4 hours or more were randomly divided into Group S and PR (n=20 each). After anesthesia induction, patients of Group S were maintained with only sevoflurane, and patients of Group PR with target-controlled infusion of propofol 2-4 microg/ml and remifentanil 4-8 ng/ml. Anesthesia was titrated to control blood pressure and heart rate change at less than 20 percent of baseline values. Blood samples were draw at pre-induction, 4 h and 24 h post-induction respectively. Serum level of cardiac troponin I, creatine kinase MB and myoglobin were analyzed.RESULTS:
There were no significant changes of troponin I, creatine kinase MB and myoglobin in Group S between pre-induction and 4 h or 24 h post-induction (P > 0.05). And there was also no significant differences as compared with Group PR (P > 0.05).CONCLUSION:
At the concentration range of 1.6%-3%, long-term sevoflurane anesthesia does not cause detectable changes of markers of myocardial damage or toxicity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Anestésicos por Inhalación
/
Éteres Metílicos
/
Miocardio
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Yi Xue Za Zhi
Año:
2009
Tipo del documento:
Article
País de afiliación:
China