The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer.
Science
; 327(5961): 84-7, 2010 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-20044575
ABSTRACT
The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin. On the basis of these results, we have generated a diagnostic marker for DFTD and identify a suite of genes relevant to DFTD pathology and transmission. We provide a genomic data set for the Tasmanian devil that is applicable to cancer diagnosis, disease evolution, and conservation biology.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células de Schwann
/
Neoplasias Faciales
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Neoplasias de la Vaina del Nervio
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Perfilación de la Expresión Génica
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Marsupiales
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos