Lung cancer risk associated with occupational exposure to nickel, chromium VI, and cadmium in two population-based case-control studies in Montreal.
Am J Ind Med
; 53(5): 476-85, 2010 May.
Article
en En
| MEDLINE
| ID: mdl-20187007
ABSTRACT
BACKGROUND:
Nickel, chromium VI, and cadmium have been identified as lung carcinogens in highly exposed cohorts. The purpose of this study was to examine the etiological link between lung cancer and these metals in occupations, that usually entail lower levels of exposure than those seen in historical cohorts.METHODS:
Two population-based case-control studies were conducted in Montreal, from 1979 to 1986 and from 1996 to 2001, comprising 1,598 cases and 1,965 controls. A detailed job history was obtained to evaluate lifetime occupational exposure to many agents, including nickel, chromium VI, and cadmium compounds.RESULTS:
Lung cancer odds ratios were increased only among former or non-smokers 2.5 (95% CI 1.3-4.7) for nickel exposure, 2.4 (95% CI 1.2-4.8) for chromium VI, and 4.7 (95% CI 1.5-14.3) for cadmium. The metals did not increase risk among smokers.CONCLUSIONS:
While excess risks due to these metal compounds were barely discernable among smokers, carcinogenic effects were seen among non-smokers.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
/
2_ODS3
Problema de salud:
1_doencas_nao_transmissiveis
/
2_muertes_prematuras_enfermedades_notrasmisibles
Asunto principal:
Cadmio
/
Carcinógenos Ambientales
/
Cromo
/
Exposición Profesional
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Neoplasias Pulmonares
/
Níquel
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Am J Ind Med
Año:
2010
Tipo del documento:
Article
País de afiliación:
Canadá