Osteomalacia as a result of vitamin D deficiency.
Endocrinol Metab Clin North Am
; 39(2): 321-31, table of contents, 2010 Jun.
Article
en En
| MEDLINE
| ID: mdl-20511054
ABSTRACT
Osteomalacia is an end-stage bone disease of chronic and severe vitamin D or phosphate depletion of any cause. Its importance has increased because of the rising incidence of vitamin D deficiency. Yet, not all cases of osteomalacia are cured by vitamin D replacement, and furthermore, not all individuals with vitamin D deficiency develop osteomalacia. Although in the past osteomalacia was commonly caused by malabsorption, nutritional deficiency now is more common. In addition, recent literature suggests that nutritional vitamin D deficiency osteomalacia follows various bariatric surgeries for morbid obesity. Bone pain, tenderness, muscle weakness, and difficulty walking are all common clinical manifestations of osteomalacia. Diagnostic work-up involves biochemical assessment of vitamin D status and may also include a transiliac bone biopsy. Treatment is based on aggressive vitamin D repletion in most cases with follow-up biopsies if patients are started on antiresorptive or anabolic agents.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteomalacia
/
Vitamina D
/
Deficiencia de Vitamina D
Tipo de estudio:
Diagnostic_studies
/
Incidence_studies
/
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
Idioma:
En
Revista:
Endocrinol Metab Clin North Am
Asunto de la revista:
ENDOCRINOLOGIA
/
METABOLISMO
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos