[Long-term survival after curative resection for oesophageal and cardia cancer]. / Sygdomsfri langtidsoverlevelse efter makroradikal operation for cancer oesophagi/cardiae.
Ugeskr Laeger
; 172(21): 1597-602, 2010 May 24.
Article
en Da
| MEDLINE
| ID: mdl-20525472
ABSTRACT
INTRODUCTION:
We present the long-term survival after curative resection for cancer at the gastro-oesophageal junction. MATERIAL ANDMETHODS:
From 1992 through 2003, 147 patients with cancer at the gastro-oesophageal junction underwent curative resection. Preoperative evaluation included a computed tomography (CT) scan of the thorax and abdomen, gastroscopy, endoscopic ultrasonography and ultrasonography of the neck.RESULTS:
Explorative laparotomy was performed in 466 patients, and 147 underwent curative resection, while 319 had advanced disease. No patients received adjuvant chemo-radiotherapy. Adenocarcinoma was found in 93% of the patients and squamous cell carcinoma in 7%. Cardia resection was performed in 78%, while 22% underwent gastrectomy. R0 resection was performed in 95% of the operations. Anastomotic dehiscence was seen in 4%. The perioperative mortality after curative resection was 3% and the 180-day-mortality was 5%. The observed five-year survival rate after curative operation was 29% and the estimated five-year survival was 24%. The five-year survival rates according to tumour stage (T1-4) were 85%, 40%, 23% and 25%, respectively. After stratification according to lymph node metastases (-/+metastases) and age below/above 70 years, five-year survival rates were 41%/ 19% and 32%/17%, respectively. Cox regression analysis showed that no metastases (N0) and age below 70 years were independent predictors of survival.CONCLUSION:
The overall and stage-dependent survival after five years, perioperative mortality and complications are acceptable and comparative to those reported by foreign centres.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Gástricas
/
Neoplasias Esofágicas
/
Carcinoma de Células Escamosas
/
Cardias
/
Adenocarcinoma
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Da
Revista:
Ugeskr Laeger
Año:
2010
Tipo del documento:
Article
País de afiliación:
Dinamarca