Extensive gene conversion drives the concerted evolution of paralogous copies of the SRY gene in European rabbits.
Mol Biol Evol
; 27(11): 2437-40, 2010 Nov.
Article
en En
| MEDLINE
| ID: mdl-20525900
ABSTRACT
The human Y chromosome consists of ampliconic genes, which are located in palindromes and undergo frequent gene conversion, and single-copy genes including the primary sex-determining locus, SRY. Here, we demonstrate that SRY is duplicated in a large palindrome in the European rabbit (Oryctolagus cuniculus). Furthermore, we show through comparative sequencing that orthologous palindrome arms have diverged 0.40% between rabbit subspecies over at least 2 My, but paralogous palindrome arms have remained nearly identical. This provides clear evidence of gene conversion on the rabbit Y chromosome. Together with previous observations in humans, these results suggest that gene conversion is a general feature of the evolution of the mammalian Y chromosome.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conejos
/
Homología de Secuencia de Ácido Nucleico
/
Dosificación de Gen
/
Evolución Molecular
/
Genes sry
/
Conversión Génica
Límite:
Animals
/
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Mol Biol Evol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2010
Tipo del documento:
Article
País de afiliación:
Portugal