Overexpression of KLF13 and FGFR3 in oral cancer cells.
Cytogenet Genome Res
; 128(4): 192-8, 2010 Jun.
Article
en En
| MEDLINE
| ID: mdl-20539070
ABSTRACT
KLF13 and FGFR3 have important cellular functions and each is believed to play a role in cancer. KLF13 is a transcription factor required for the expression of several oncogenes. FGFR3 is a fibroblast growth factor receptor that initiates a signaling cascade leading to the activation of numerous cellular pathways. Here we show that KLF13 and FGFR3 are overexpressed in oral cancer cells. We also show that artificially reducing cellular levels of KLF13 and FGFR3 decreases cell proliferation and increases sensitivity to ionizing radiation. These data suggest that KLF13 and FGFR3 contribute to malignancy in oral cancer cells and may be useful biomarkers for early detection and possible targets for therapy.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Represoras
/
Neoplasias de la Boca
/
Carcinoma de Células Escamosas
/
Regulación Neoplásica de la Expresión Génica
/
Proteínas de Ciclo Celular
/
Receptor Tipo 3 de Factor de Crecimiento de Fibroblastos
/
Factores de Transcripción de Tipo Kruppel
Tipo de estudio:
Screening_studies
Límite:
Adult
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cytogenet Genome Res
Asunto de la revista:
GENETICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos