[Myocardial protection against global ischemia-reperfusion with use of Krebs-Henseleit buffer-based cardioplegic solution].
Ross Fiziol Zh Im I M Sechenova
; 96(4): 353-61, 2010 Apr.
Article
en Ru
| MEDLINE
| ID: mdl-20564956
ABSTRACT
Improvement of myocardial protection against global ischemia-reperfusion injury during cardiopulmonary bypass remains to be of primary importance for cardiac surgery. In the present study, the effectiveness of new Krebs-Henseleit buffer-based cardioplegic solution was investigated in an isolated rat heart preparation in normo- and hypothermic states. Use of this crystalloid cardioplegic solution in the normothermic mode (37 degrees C) resulted in better myocardial protection in comparison to standard cardioplegic solutions as evidenced from both infarct size data and the patterns of left ventricular postischemic recovery. The data obtained indicate that Krebs-Henseleit buffer-based cardioplegic solution might be recommended for further preclinical testing.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Soluciones Cardiopléjicas
/
Daño por Reperfusión Miocárdica
/
Infarto del Miocardio
Límite:
Animals
Idioma:
Ru
Revista:
Ross Fiziol Zh Im I M Sechenova
Asunto de la revista:
FISIOLOGIA
Año:
2010
Tipo del documento:
Article