Hypoxia tolerance in animals: biology and application.
Physiol Biochem Zool
; 83(5): 733-52, 2010.
Article
en En
| MEDLINE
| ID: mdl-20565233
ABSTRACT
Many invertebrates and ectothermic vertebrates successfully cope with a fluctuating supply of ambient oxygen-and consequently, a highly variable tissue oxygenation-through increasing their antioxidant barriers. During chronic deprivation of oxygen, however, the hypometabolic defense mode of the fruit fly Drosophila, the hypoxia-induced behavioral hypothermia of the crayfish Pacifastacus leniusculus, and the production of ethanol during anoxia by the crucian carp Carassius carassius all indicate that these animals are also capable of utilizing a suite of genetic and physiological defenses to survive otherwise lethal reductions in tissue oxygenation. Normally, much of an organism's gene response to hypoxia is orchestrated via the hypoxia-inducible transcription factor HIF. Recent developments expand our view of HIF function even further by highlighting regulatory roles for HIF in the hypometabolism of insects, in the molting and the normoxic immune response of crustaceans, and in the control-via the downstream effector gene erythropoietin-of the hypoxic ventilatory response and pulmonary hypertension in mammals. These and related topics were collectively presented by the authors in a symposium of the 2008 ICA-CBP conference at Mara National Reserve, Kenya, Africa. This synthesis article communicates the essence of the symposium presentations to the wider community.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxígeno
/
Adaptación Fisiológica
/
Estrés Oxidativo
/
Factor 1 Inducible por Hipoxia
/
Hipoxia
Límite:
Animals
Idioma:
En
Revista:
Physiol Biochem Zool
Asunto de la revista:
BIOLOGIA
/
FISIOLOGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Suiza