Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors.
Bioorg Med Chem Lett
; 20(14): 4156-8, 2010 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-20621728
ABSTRACT
A novel series of pyrrole inhibitors of MEK kinase has been developed using structure-based drug design. Optimization of the series led to the identification of potent inhibitors with good pharmaceutical properties.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pirroles
/
Quinasas Quinasa Quinasa PAM
/
Inhibidores de Proteínas Quinasas
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos
