17-N-Allylamino-17-demethoxygeldanamycin induces a diverse response in human acute myelogenous cells.
Leuk Res
; 34(11): 1493-500, 2010 Nov.
Article
en En
| MEDLINE
| ID: mdl-20646760
ABSTRACT
The goal of this study was to ascertain the specific effects of 17-N-Allylamino-17-demethoxygeldanamycin (17-AAG) treatment in human acute myelogenous leukemia (AML). Four human leukemia cell lines were treated with varying doses of 17-AAG followed by analysis of toxicity, apoptosis, proliferation, and cell cycle. Cell cycle analysis revealed that the cells accumulate in G2/M phase within 96 h of treatment, although the effect was not equivalent among the cell lines. p21, p53 expression and MDR1 activity were among the possible mechanisms uncovered for the differing responses. Exploiting these differences may allow for more effective combinatory treatments in patients with AML.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucemia Mieloide Aguda
/
Benzoquinonas
/
Lactamas Macrocíclicas
Límite:
Humans
Idioma:
En
Revista:
Leuk Res
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos