Acute myocardial infarction in a patient with chronic myelocytic leukemia during chemotherapy with hydroxyurea.
Herz
; 35(6): 420-2, 2010 Sep.
Article
en En
| MEDLINE
| ID: mdl-20721521
ABSTRACT
BACKGROUND:
Cardiac toxicity is a known side effect of chemotherapeutics such as 5-fluorouracil (5-FU) or cisplatin. Chest pain with ECG changes, arrhythmias, acute myocardial infarction (AMI), heart failure and sudden death have been described in the literature. CASE STUDY We report the first case of AMI in a 59-year-old male patient with chronic myelocytic leukemia (CML) during chemotherapy with hydroxyurea. The patient was not affected by prior heart disease and did not reveal any classic risk factors for coronary heart disease. Because of the severe thrombocytopenia (23000/µl), no acetylsalicylic acid (ASA) or clopidogrel were given but low dose heparin (400 U/h). Urgent coronary angiography revealed complete thrombotic occlusion of the proximal left descending coronary artery.CONCLUSION:
This case reveals that AMI can occur during chemotherapy with hydroxyurea in patients without prior heart disease. The pathogenesis of this phenomenon remains hitherto unclear. Coronary artery spasm, lesions of the endothelium as well as coagulation disorders have been postulated to explain this side effect of hydroxyurea.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trombosis Coronaria
/
Leucemia Mielógena Crónica BCR-ABL Positiva
/
Infarto de la Pared Anterior del Miocardio
/
Hidroxiurea
/
Antineoplásicos
Tipo de estudio:
Diagnostic_studies
/
Risk_factors_studies
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Herz
Año:
2010
Tipo del documento:
Article
País de afiliación:
Alemania