Synthesis of potent, substituted carbazoles as selective androgen receptor modulators (SARMs).
Bioorg Med Chem Lett
; 20(24): 7516-20, 2010 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-21036041
ABSTRACT
The synthesis and in vitro binding affinity for a novel series of potent androgen receptor modulators is described. One of the more potent compounds (17, RAD35010) was further characterized in vivo where it restored levator ani weight in castrated male rats to near sham level while having no significant effect on prostate weight.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carbazoles
/
Receptores Androgénicos
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos
