A positive relationship between filamin and VEGF in patients with lung cancer.
Anticancer Res
; 30(10): 3939-44, 2010 Oct.
Article
en En
| MEDLINE
| ID: mdl-21036706
Induction of angiogenic responses by multiple factors, a crucial step in tumor growth and metastasis, is not completely understood. Recently, involvement of the cytoskeletal actin-binding proteins in angiogenesis has been suggested as a target for anti-neovascular cancer therapy in vitro. In this study, the expression of filamin A (FLNA) and vascular endothelial growth factor (VEGF) in paraffin-embedded tumor samples from patients with well-characterized lung tumors was immunohistochemically analyzed and compared with clinical variables and survival outcome. A positive expression of FLNA and VEGF was detected in the cytoplasm of tumor cells in 66 (48.2%) and 69 (50.4%) of the 137 patients with lung cancer, respectively (p<0.0001). A significant difference was observed between FLNA expression and VEGF expression. Although our findings do not suggest that the expression of FLNA alone plays an independent prognostic role, the angiogenesis pathway mediated by FLNA appears to be responsible for controlling the growth of lung tumors.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Contráctiles
/
Miembro 15 de la Superfamilia de Ligandos de Factores de Necrosis Tumoral
/
Neoplasias Pulmonares
/
Proteínas de Microfilamentos
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Anticancer Res
Año:
2010
Tipo del documento:
Article
País de afiliación:
Japón