Microglia activation is related to substantia nigra echogenicity.
J Neural Transm (Vienna)
; 117(11): 1287-92, 2010 Nov.
Article
en En
| MEDLINE
| ID: mdl-21057966
ABSTRACT
Hyperechogenicity of the substantia nigra (SN) is a sensitive marker for Parkinson's disease (PD). Previously, a relation between SN echogenicity and iron as well as neuromelanin content could be described in 60 human brains. In the present study on a subset of 33 brains, SN echogenicity was found to be correlated with microglia activation (ρ = 0.46, p = 0.008) after correction for iron and neuromelanin content. These findings strengthen the hypothesis of a close pathophysiological connection between SN hyperechogenicity and PD pathology.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Sustancia Negra
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Microglía
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Neural Transm (Vienna)
Año:
2010
Tipo del documento:
Article
País de afiliación:
Alemania