Methylation of AKAP12{alpha} promoter in lung cancer.
Anticancer Res
; 30(11): 4595-600, 2010 Nov.
Article
en En
| MEDLINE
| ID: mdl-21115911
ABSTRACT
AKAP12α plays an important role in tumour growth suppression by inducing apoptosis. This study investigated whether the promoter methylation of AKAP12α is associated with lung cancer. AKAP12α was down-regulated in lung cancer cells and the reduced protein expression was restored by DNA methyl-transferase inhibitor. AKAP12α promoter was more frequently methylated in tumours than in normal tissues. Furthermore, AKAP12α methylation was found more frequently in the cells of non-relapse patients after surgery than in those of early relapse patients. In conclusion, this study demonstrated that AKAP12α expression is regulated by DNA methylation and that AKAP12α promoter methylation is associated with lung cancer prognosis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Regulación Neoplásica de la Expresión Génica
/
Regiones Promotoras Genéticas
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Carcinoma de Pulmón de Células no Pequeñas
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Proteínas de Ciclo Celular
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Metilación de ADN
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Proteínas de Anclaje a la Quinasa A
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Neoplasias Pulmonares
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Recurrencia Local de Neoplasia
Límite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Anticancer Res
Año:
2010
Tipo del documento:
Article