[Effects of vitamin E on expression of PS-1 and production of Abeta in the hippocampus of female senile rats].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
; 23(2): 237-40, 2007 May.
Article
en Zh
| MEDLINE
| ID: mdl-21179780
ABSTRACT
AIM:
To observe the expression of Presenilin-1 (PS-1) and production of amyloid beta-protein (Abeta) in hippocampus of female senile rats and to investigate the effect of vitamin E(VE) on preventing Alzheimer's disease after menopause.METHODS:
The animal model was established using female senile rats. Experimental groups (n=8) were respectively given different doses of VE(5 mg/kg, 15 mg/kg, 60 mg/kg) per day. The expression of PS-1 in hippocampus was detected by immunohistochemistry, the level of Abeta in hippocampus was measured by Radioimmunoassay, and neuronal ultrastructure in hippocampal DG area was observed using transmission electron microscope.RESULTS:
The expression of PS-1 in rat hippocampus of senile control group was stronger than that of adult control group. PS-1 expressed weakly in three medication groups along with augmentation of dosage. The levels of Abeta were found to correlate statistically with the expression of PS-1. The content of Abeta in VE groups was significantly decreased compared to that in senile control group (P < 0.01). There were some changes in the neuronal ultrastructure of senile rats. Neurons were gradually recovered in VE groups.CONCLUSION:
VE may depress the production of Abeta by regulating the expression of PS-1, reducing neuronal injuries. VE may play a role in neuronal protection.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vitamina E
/
Péptidos beta-Amiloides
/
Presenilina-1
/
Enfermedad de Alzheimer
/
Hipocampo
Límite:
Animals
Idioma:
Zh
Revista:
Zhongguo Ying Yong Sheng Li Xue Za Zhi
Asunto de la revista:
FISIOLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
China