Chapter 1--importance of chloride homeostasis in the operation of rhythmic motor networks.
Prog Brain Res
; 188: 3-14, 2011.
Article
en En
| MEDLINE
| ID: mdl-21333799
ABSTRACT
GABA and glycine are classically called "inhibitory" amino acids, despite the fact that their action can rapidly switch from inhibition to excitation and vice versa. The postsynaptic action depends on the intracellular concentration of chloride ions ([Cl(-)](i)), which is regulated by proteins in the plasma membrane the K(+)-Cl(-) cotransporter KCC2 and the Na(+)-K(+)-Cl(-) cotransporter NKCC1, which extrude and intrude Cl(-) ions, respectively. A high [Cl(-)](i) leads to a depolarizing (excitatory) action of GABA and glycine, as observed in mature dorsal root ganglion neurons and in motoneurons both early during development and in several pathological conditions, such as following spinal cord injury. Here, we review some recent data regarding chloride homeostasis in the spinal cord and its contribution to network operation involved in locomotion.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Periodicidad
/
Cloruros
/
Homeostasis
/
Locomoción
/
Red Nerviosa
Límite:
Animals
Idioma:
En
Revista:
Prog Brain Res
Año:
2011
Tipo del documento:
Article
País de afiliación:
Francia