TNF-α downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-α antagonists to improve skin barrier.
J Invest Dermatol
; 131(6): 1272-9, 2011 Jun.
Article
en En
| MEDLINE
| ID: mdl-21346775
ABSTRACT
Filaggrin (FLG), loricrin (LOR), and involucrin are important epidermal barrier proteins. As psoriasis is characterized by overexpression of tumor necrosis factor-α (TNF-α) and impaired skin barrier, we investigated the expression of skin barrier proteins in psoriasis patients and whether their expression was modulated by TNF-α. The expression of FLG and LOR was found to be decreased in lesional and non-lesional skin of psoriasis patients. A correlation was found between the expression of TNF-α and epidermal barrier proteins in psoriasis. TNF-α was found to modulate the expression of FLG and LOR via a c-Jun N-terminal kinase-dependent pathway. Importantly, we report that clinical treatment of psoriasis patients with a TNF-α antagonist results in significant enhancement of epidermal barrier protein expression. Our current study suggests that TNF inhibits barrier protein expression, and TNF-α antagonists may contribute to clinical improvement in patients with psoriasis by improving barrier protein expression.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Psoriasis
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Piel
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Factor de Necrosis Tumoral alfa
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Proteínas Quinasas JNK Activadas por Mitógenos
/
Proteínas de Filamentos Intermediarios
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Proteínas de la Membrana
Límite:
Adult
/
Humans
Idioma:
En
Revista:
J Invest Dermatol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos