[In vitro absorption mechanism of strychnine and the transport interaction with liquiritin in Caco-2 cell monolayer model].
Yao Xue Xue Bao
; 45(9): 1160-4, 2010 Sep.
Article
en Zh
| MEDLINE
| ID: mdl-21351573
ABSTRACT
To study the effect of liquiritin (Liq) on the transport of strychnine (Str) in Caco-2 cell monolayer model, the transport parameters of Str, such as apparent permeability coefficient (P app (B-->A) and P app (A-->B)) and cumulative transport amount (TRcum), were determined and comparatively analyzed when Str was used solely and co-used with Liq. The effect of drug concentrations, conveying times, P-glycoprotein (P-gp) inhibitor verapamil and conveying liquor pH values on the transport of Str were also investigated. The results indicated that the absorption of Str in Caco-2 cell monolayer model was well and the passive transference was the main intestinal absorption mechanism of Str in the Caco-2 monolayer model, along with the excretion action mediated by P-gp. Liq enhanced the absorption of Str. Meanwhile, conveying liquor pH value had significant influence on the excretion transport of Str.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estricnina
/
Flavanonas
/
Glucósidos
Límite:
Humans
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Año:
2010
Tipo del documento:
Article
País de afiliación:
China