Regulatory T-cell adoptive immunotherapy: potential for treatment of autoimmunity.
Expert Rev Clin Immunol
; 7(2): 213-25, 2011 Mar.
Article
en En
| MEDLINE
| ID: mdl-21426259
ABSTRACT
Tregs have shown considerable potential in treating preclinical models of autoimmunity. These studies have highlighted the importance of Treg antigen (Ag) specificity. Translation of these promising results to the clinic will require a robust method of generating large pure populations of Ag-specific Tregs. These include the recently described T-cell receptor gene transfer approach, which has proven to be a rapid and reliable method to generate large populations of Ag-specific Tregs. In this article, we will examine these various approaches and discuss their relative merits. Furthermore, we will discuss the obstacles that need to be surmounted to allow adoptive Treg therapy to progress to the clinic for the benefit of autoimmune patients.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Autoinmunes
/
Inmunoterapia Adoptiva
/
Linfocitos T Reguladores
/
Especificidad del Receptor de Antígeno de Linfocitos T
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Expert Rev Clin Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido