Molecular X-ray computed tomography of myelin in a rat brain.
Neuroimage
; 57(1): 124-129, 2011 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-21514390
ABSTRACT
In this work we demonstrate the feasibility of applying small-angle X-ray scattering computed tomography (SAXS-CT) for non-invasive molecular imaging of myelin sheaths in a rat brain. Our results show that the approach yields information on several quantities, including the relative myelin concentration, its periodicity, the total thickness of the myelin sheaths, and the relative concentration of cytoskeletal neurofilaments. For example the periodicity of the myelin sheaths varied in the range from 17.0 to 18.2 nm around an average of 17.6 (±0.3) nm. We believe that imaging, i.e., spatially resolved measuring these quantities could provide general means for understanding the relation to a number of neurodegenerative diseases.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Difracción de Rayos X
/
Encéfalo
/
Tomografía Computarizada por Rayos X
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Imagenología Tridimensional
/
Dispersión del Ángulo Pequeño
/
Vaina de Mielina
Límite:
Animals
Idioma:
En
Revista:
Neuroimage
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2011
Tipo del documento:
Article