[Effect of ghrelin on duodenal migrating myoelectric complex in rats with chronic renal failure].
Nan Fang Yi Ke Da Xue Xue Bao
; 31(4): 624-7, 2011 Apr.
Article
en Zh
| MEDLINE
| ID: mdl-21515456
ABSTRACT
OBJECTIVE:
To investigate the effect of ghrelin on duodenal migrating myoelectric complex (MMC) in rats with chronic renal failure (CRF).METHODS:
Thirty healthy male SD rats were randomly assigned into sham-operated group (n=6) and CRF group (n=24), and the latter group was divided into 4 subgroups according to ghrelin doses administered with or without pretreatment with the receptor antagonist D-Lys(3)-GHRP-6. After a 18-h fasting, the rats with or without pretreatment with D-Lys(3)-GHRP-6 were given subcutaneous injections of ghrelin at different doses to observe the changes in duodenal MMC recorded using a multi lead physiological recording system.RESULTS:
Ghrelin significantly increased the MMC cycle duration and dose-dependently enhanced the frequency, amplitude and percentage of phase III MMC cycle. This effect was inhibited by the pretreatment with ghrelin receptor antagonist D-Lys(3)-GHRP-6.CONCLUSION:
Ghrelin can promote gastrointestinal motilities of rats with CRF, and the receptor of ghrelin can regulate the activity of MMC.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Complejo Mioeléctrico Migratorio
/
Duodeno
/
Ghrelina
/
Motilidad Gastrointestinal
/
Fallo Renal Crónico
Límite:
Animals
Idioma:
Zh
Revista:
Nan Fang Yi Ke Da Xue Xue Bao
Año:
2011
Tipo del documento:
Article
País de afiliación:
China