Fibroblasts have plasticity and potential utility for cell therapy.
Hum Cell
; 24(1): 30-4, 2011 Mar.
Article
en En
| MEDLINE
| ID: mdl-21547693
ABSTRACT
Fibroblasts exist in the interstices of various organs as a component of connective tissue and are one of several types of somatic cells that have been well established in culture. They have been reported to undergo myogenic conversion and to induce the expression of genes associated with pluripotency. However, their own plasticity with regard to direct differentiation has scarcely been described. Here, we show that human fibroblasts are able to differentiate directly to all three germ layer derivatives. The results indicate that human dermal fibroblasts have more plasticity than has been generally thought and that fibroblasts have potential utility as a source for cell therapy.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Diferenciación Celular
/
Fibroblastos
Límite:
Humans
Idioma:
En
Revista:
Hum Cell
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón