Perfusion method for bone marrow cell collection in poor mobilizer lymphoma patient.
Int J Hematol
; 93(6): 822-824, 2011 Jun.
Article
en En
| MEDLINE
| ID: mdl-21597911
ABSTRACT
We previously described a unique procedure for the collection of bone marrow cells (BMCs) using a perfusion method (PM). In cynomolgus monkeys, this method resulted in lower contamination with T cells (<10%). Here, we performed PM on a poor mobilizer lymphoma patient. We confirmed the safety of the intra-bone marrow injection of saline to collect the BMCs. The collected BMCs showed minimal contamination with T cells (<15%) and red blood cells (RBCs) (<4%) from the peripheral blood. It took a total of only 30 min to collect the BMCs. Moreover, transfusion of RBCs was unnecessary. There were no relevant post-operative side effects except for self-limiting pain at the sites of collection, and the patient was able to walk around the hospital after the operation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Perfusión
/
Células de la Médula Ósea
/
Linfoma de Células B Grandes Difuso
/
Trasplante de Células Madre Hematopoyéticas
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Hematol
Asunto de la revista:
HEMATOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón