C-Myb function in the vessel wall.
Front Biosci (Elite Ed)
; 3(3): 968-77, 2011 06 01.
Article
en En
| MEDLINE
| ID: mdl-21622105
ABSTRACT
C-Myb is a DNA-binding transcription factor that functions in apoptosis, proliferation and differentiation. The role of c-Myb in vascular injury has been investigated previously both in vitro and in vivo, where knock-down of c-Myb is known to lead to a reduction in proliferation and an increase in apoptosis of vascular smooth muscle cells (VSMCs). Reduction of c-Myb activity has also been shown to decrease neointimal formation in vivo, by reducing VSMC proliferation. In contrast, over-expression of c-Myb in vivo leads to increased survival rates in certain cell types. This review will look mainly at studies investigating c-Myb function in the vasculature, and evidence of signalling interactions which may be considered with regard to c-Myb as a possible target in the treatment of vasculoproliferative diseases.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vasos Sanguíneos
/
Endotelio Vascular
/
Túnica Íntima
/
Proteínas Proto-Oncogénicas c-myb
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Front Biosci (Elite Ed)
Asunto de la revista:
BIOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido