Mesothelin and GPR30 staining among a spectrum of pancreatic epithelial neoplasms.
Int J Surg Pathol
; 19(5): 588-96, 2011 Oct.
Article
en En
| MEDLINE
| ID: mdl-21632639
ABSTRACT
INTRODUCTION:
Our study attempts to characterize mesothelin and GPR30 / estrogen receptor (ER) staining in pancreatic pathology. MATERIALS ANDMETHODS:
Immunohistochemical staining for mesothelin, GPR30, and ER was performed on a variety of pancreatic lesions.RESULTS:
24 of 42 (57%) adenocarcinomas stained for mesothelin, while 0 of 16 non-carcinomas (0%) stained (p = 0.0000784). 35 of 39 (90%) adenocarcinomas stained for GPR30, while only 4 of 15 (27%) non-carcinomas stained (p = 0.0000036). Apart from stromal staining in one case of mucinous cystic neoplasm, no cases stained for ER. 27 of 37 (73%) adenocarcinoma fine needle aspirates were positive for mesothelin.DISCUSSION:
GPR30 is more sensitive, but less specific than mesothelin for pancreatic adenocarcinoma. Mesothelin is detected in most adenocarcinoma fine needle aspirates. ER is rarely detected in pancreatic lesions.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Pancreáticas
/
Receptores de Estrógenos
/
Biomarcadores de Tumor
/
Neoplasias Glandulares y Epiteliales
/
Receptores Acoplados a Proteínas G
/
Proteínas Ligadas a GPI
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Int J Surg Pathol
Asunto de la revista:
PATOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos