Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives.
Eur J Med Chem
; 46(9): 3845-50, 2011 Sep.
Article
en En
| MEDLINE
| ID: mdl-21680063
ABSTRACT
A number of 7-hydroxycoumarins have been synthesised by Pechmann cyclisation using differently substituted resorcinols employing perchloric acid as the condensing agent. All the compounds have been characterised by analytical and spectroscopic methods. The anti-inflammatory properties were tested with LPS-induced inflammation in J774 macrophages. Expression of iNOS and COX-2 was determined by Western blot, NO by nitrite assay and IL-6 by ELISA analyses. Fifteen of the tested 7-hydroxycoumarins also inhibited IL-6 production but none of them had any major inhibitory effect on COX-2 expression.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Umbeliferonas
/
Antiinflamatorios
Límite:
Animals
Idioma:
En
Revista:
Eur J Med Chem
Año:
2011
Tipo del documento:
Article
País de afiliación:
Finlandia