Targeting the erythropoietin receptor on glioma cells reduces tumour growth.
Exp Cell Res
; 317(16): 2321-32, 2011 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-21749867
ABSTRACT
Hypoxia has been shown to be one of the major events involved in EPO expression. Accordingly, EPO might be expressed by cerebral neoplastic cells, especially in glioblastoma, known to be highly hypoxic tumours. The expression of EPOR has been described in glioma cells. However, data from the literature remain descriptive and controversial. On the basis of an endogenous source of EPO in the brain, we have focused on a potential role of EPOR in brain tumour growth. In the present study, with complementary approaches to target EPO/EPOR signalling, we demonstrate the presence of a functional EPO/EPOR system on glioma cells leading to the activation of the ERK pathway. This EPO/EPOR system is involved in glioma cell proliferation in vitro. In vivo, we show that the down-regulation of EPOR expression on glioma cells reduces tumour growth and enhances animal survival. Our results support the hypothesis that EPOR signalling in tumour cells is involved in the control of glioma growth.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Encefálicas
/
Transducción de Señal
/
Receptores de Eritropoyetina
/
Glioma
Idioma:
En
Revista:
Exp Cell Res
Año:
2011
Tipo del documento:
Article
País de afiliación:
Francia