Cutaneous manifestations in CMML: Indication of disease acceleration or transformation to AML and review of the literature.
Leuk Res
; 36(1): 72-80, 2012 Jan.
Article
en En
| MEDLINE
| ID: mdl-21782240
ABSTRACT
Our retrospective analysis explored the role of leukemia cutis (LC) in disease progression of chronic myelomonocytic leukemia (CMML). Of 108 patients with CMML, 11 patients (10.2%) had LC including its equivalent (2 patients). Four of these patients developed acute myeloid leukemia (AML) within 0-4 months. The remaining 7 patients demonstrated increased monocytes (<20% blasts), with 3 demonstrating extramedullary involvement. Overall survival from LC to disease progression was 7.8 months. Overall survival from diagnosis to the last follow-up in patients with LC was 28.2 months, shorter than patients without LC (44 months). LC and its equivalent could predict disease progression to AML.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Leucemia Mielomonocítica Crónica
/
Leucemia Mieloide Aguda
/
Transformación Celular Neoplásica
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Leuk Res
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos