Give boron a chance: boron containing compounds reach ionotropic and metabotropic transmembrane receptors.
Mini Rev Med Chem
; 11(12): 1031-8, 2011 Oct.
Article
en En
| MEDLINE
| ID: mdl-21861808
ABSTRACT
The ligand-gated ion channels and seven transmembrane domain receptors are the greatest families of transmembrane receptors (TMR) expressed in mammalians and the major target of current available drugs. Recently, boron containing compounds (BCC) have shown capability of acting as ligands on these targets. This mini-review is focused on the description of BCC that target TMR which were evaluated under experimental models. The results in experimental models are related with the theoretical interaction studies of these ligands on the target proteins as 3D-models in order to explore the biological effects of BCC in molecular detail.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos de Boro
/
Receptores de Glutamato Metabotrópico
/
Receptores Ionotrópicos de Glutamato
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Mini Rev Med Chem
Asunto de la revista:
QUIMICA
Año:
2011
Tipo del documento:
Article