Messenger RNA expression and genetic polymorphisms of cell cycle control genes and chromosomal aberrations in Chinese vinyl chloride monomer-exposed workers.
J Occup Environ Med
; 53(12): 1442-6, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-22076037
ABSTRACT
OBJECTIVE:
To evaluate the expressions of p53, p21, and CCND1 in the peripheral blood lymphocytes of vinyl chloride monomer (VCM)-exposed workers and potential relationships with their exposures, polymorphisms, and chromosomal aberrations.METHODS:
The study was performed on 77 occupationally VCM-exposed workers and 43 unexposed controls. The quantities of mRNA expression of p53, p21, and CCND1 genes were detected by real-time polymerase chain reaction.RESULTS:
p53 mRNA expression of VCM-low- and high-exposure groups was significantly lower than that of nonexposed group (P < 0.001), but p21 mRNA expression of the two VCM-exposed groups was significantly higher than that of the nonexposed group (P < 0.001). This study did not find the relationship between chromosomal aberrations, genotypes, and the expression of p53, p21, and CCND1.CONCLUSIONS:
Messenger RNA expressions of p53 and p21 are changed with VCM-exposure status.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Cloruro de Vinilo
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ARN Mensajero
/
Exposición Profesional
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Aberraciones Cromosómicas
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Pueblo Asiatico
/
Puntos de Control del Ciclo Celular
Límite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Occup Environ Med
Asunto de la revista:
MEDICINA OCUPACIONAL
/
SAUDE AMBIENTAL
Año:
2011
Tipo del documento:
Article
País de afiliación:
China