Actin cytoskeleton remodelling by sex steroids in neurones.
J Neuroendocrinol
; 24(1): 195-201, 2012 Jan.
Article
en En
| MEDLINE
| ID: mdl-22103470
ABSTRACT
Cell morphology and its interaction with the extracellular environment are integrated processes involving a number of intracellular controllers orchestrating cytoskeletal proteins and their interaction with the cell membrane and anchorage proteins. Sex steroids are effective regulators of cell morphology and tissue organisation, and recent evidence indicates that this is obtained through the regulation of the actin cytoskeleton. Intriguingly, many of these regulatory actions related to cell morphology are achieved through the rapid, nonclassical signalling of sex steroid receptors to kinase cascades, independently from nuclear alteration of gene expression or protein synthesis. The identification of the mechanistic basis for these rapid actions on cell cytoskeleton has special relevance for the characterisation of the effects of sex steroids under physiological conditions, such as for the development of neurone/neurone interconnections and dendritic spine density. This is considered to be critical for gender-specific differences in brain function and dysfunction. Recent advancements in the characterisation of the molecular basis of the extranuclear signalling of sex steroids help to clarify the role of oestrogen and progesterone in the brain, and may turn out to be of relevance for clinical purposes. This review highlights the regulatory effects of oestrogens and progesterone on actin cytoskeleton and neurone morphology, as well as recent progresses in the characterisation of these mechanisms, providing insights and working hypotheses on possible clinical applications for the modulation of these pathways in the central nervous system.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hormonas Esteroides Gonadales
/
Citoesqueleto de Actina
/
Espinas Dendríticas
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
J Neuroendocrinol
Asunto de la revista:
ENDOCRINOLOGIA
/
NEUROLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Argentina