Modulation of fibrosis in systemic sclerosis by nitric oxide and antioxidants.
Cardiol Res Pract
; 2012: 521958, 2012.
Article
en En
| MEDLINE
| ID: mdl-22111028
ABSTRACT
SYSTEMIC SCLEROSIS (SCLERODERMA SSc) is a multisystem, connective tissue disease of unknown aetiology characterized by vascular dysfunction, autoimmunity, and enhanced fibroblast activity resulting in fibrosis of the skin, heart, and lungs, and ultimately internal organ failure, and death. One of the most important and early modulators of disease activity is thought to be oxidative stress. Evidence suggests that the free radical nitric oxide (NO), a key mediator of oxidative stress, can profoundly influence the early microvasculopathy, and possibly the ensuing fibrogenic response. Animal models and human studies have also identified dietary antioxidants, such as epigallocatechin-3-gallate (EGCG), to function as a protective system against oxidative stress and fibrosis. Hence, targeting EGCG may prove a possible candidate for therapeutic treatment aimed at reducing both oxidant stress and the fibrotic effects associated with SSc.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
6_immune_disorders
/
6_musculoskeletal_diseases_rheumatic_disorders
Idioma:
En
Revista:
Cardiol Res Pract
Año:
2012
Tipo del documento:
Article
País de afiliación:
Reino Unido