Use of comparative genomics approaches to characterize interspecies differences in response to environmental chemicals: challenges, opportunities, and research needs.
Toxicol Appl Pharmacol
; 271(3): 372-85, 2013 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-22142766
Palabras clave
-omics; 2,3,7,8-tetrachlorodibenzo-p-dioxin; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); ADME; APAP; AhR; Biological pathway; Cross-species; DBP; DNA; DRE; EGBE; EPA; Environmental Protection Agency; HMGCS2; Human health risk assessment; IRIS; Integrated Risk Information System; JUN; LOAEL; MOA; MYC; Molecular network; N-acetyl-p-aminophenol; NOAEL; NRC; National Research Council; PID; PPARα; PXR; RNA; RfC; RfD; Selective constraints; Systems biology; TCDD; TD; TK; absorption, distribution, metabolism, and excretion; aryl hydrocarbon receptor; deoxyribonucleic acid; dibutyl phthalate; dioxin response element; ethylene glycol monobutyl ether; jun proto-oncogene; lowest-observed-adverse-effect-level; mode of action; myelocytomatosis oncogene; no-observed-adverse-effect-level; percent identity; peroxisome proliferator activated receptor alpha; pregnane X receptor; reference concentration; reference dose; ribonucleic acid; toxicodynamic; toxicokinetic
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
/
2_ODS3
Problema de salud:
1_sistemas_informacao_saude
/
2_quimicos_contaminacion
Asunto principal:
Genómica
/
Contaminantes Ambientales
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Toxicol Appl Pharmacol
Año:
2013
Tipo del documento:
Article
