[P53 expression in liver tissue of patients with chronic hepatitis B and its influencing factors].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
; 25(5): 322-4, 2011 Oct.
Article
en Zh
| MEDLINE
| ID: mdl-22338213
ABSTRACT
OBJECTIVE:
To observe p53 expression in liver tissue of patients with chronic hepatitis B and its influencing factors.METHODS:
17 cases HBeAg-negative chronic hepatitis B patients and 31 cases HBeAg-positive chronic hepatitis B patients were divided into 2 groups.RESULTS:
(1) HBeAg-negative chronic hepatitis B patients were older, mostly male and HBV DNA lower. These three indicators between two groups patients appeared statistical difference. Serum markers were no statistical difference between two groups patients except Glo. (2) Pathological inflammation and fibrosis Staging were no statistical difference between two groups patients. p53 expression positive rate and p53 expression semi-quantitative scoring in liver tissue were no statistical difference between the two groups. (3) Logistic regression analysis showed that only liver fibrosis staging (S) is a risk factor for p53 expression. Compared with the S0-1, p53 expression increased by 3.9 times the rate of positive in S > or = 2.CONCLUSION:
Liver fibrosis staging in patients with chronic hepatitis B is a risk factor for p53 positive expression in liver.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteína p53 Supresora de Tumor
/
Hepatitis B Crónica
/
Hígado
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
Asunto de la revista:
VIROLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
China